Development &
Disease Biology
Laboratory
About PI
Dr. Debdeep Dutta is an assistant professor at the Department of Biological Sciences and Bioengineering at IIT Kanpur. He obtained his M.Sc. and Ph.D. from Banaras Hindu University, Varanasi. Prior to joining IIT Kanpur, he completed postdoctoral research in Prof. Hugo J. Bellen's lab at Duncan Neurological Research Institute and Baylor College of Medicine. His research primarily focuses on the molecular and genetic mechanisms underlying development and disease, with a particular emphasis on developmental and neurological disorders. Beyond his research, Dr. Dutta is committed to fostering a collaborative scientific environment and mentoring the next generation of researchers in biomedical science.
Professional Experience
2024 - Present
Assistant Professor, Dept. of Biological Sciences & Bioengineering, IIT Kanpur
Investigator, Mehta Family Centre for Engineering in Medicine, IIT Kanpur
Training and Education
2019 - 2024
Postdoctoral Fellow,
Duncan Neurological Research Institute &
Dept. of Molecular & Human Genetics
Baylor College of Medicine, Houston, US
2013 - 2018
Ph.D. (Cellular Signalling)
Dept. of Molecular & Human Genetics
Banaras Hindu University, Varanasi, India
2010 - 2012
M.Sc. in Zoology (Major: Molecular & Human Genetics)
Banaras Hindu University, Varanasi, India
Fellowships
2024
2022 - 2023
2013 - 2018
2011
Ramalingaswami Re-entry Fellowship
Dept. of Biotechnology, Govt. of India
Shan and Lee-Jun Wong Fellowship
Baylor College of Medicine, US
Junior & Senior Research Fellowship
Council of Scientific and Industrial Research, Govt. of India
Summer Research Fellowship
Indian Academy of Sciences, Govt. of India
Awards & Achievements
2024 - Present
2024
2023
2018 - 2020
2015
2012
2010
Early Career Reviewer for eLife
Best Publication Award,
Dept. of Molecular & Human Genetics, Baylor College of Medicine
Trainee Award for Excellence in Human Genetics Research (semifinalist), The American Society of Human Genetics
Early Career Reviewer for the Genetics Society of America journals: GENETICS and G3: Genes, Genomes, Genetics
Best Oral Presentation award in 39th All India Cell Biology Conference at IISER-TVM, Thiruvananthapuram, India
Qualified Joint CSIR-UGC test for Junior Research Fellowship and
Eligibility for Lectureship (NET), Govt. of India (Rank 55)
1st Rank for B.Sc. (Hons.) course at the Burdwan University
Key Publications
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Dutta D, Kanca O, Shridharan RV, Marcogliese PC, Steger B, Morimoto M, Frost FG, MacnamaraE, Undiagnosed Diseases Network, Wangler MF, Yamamoto S, Jenny A, Adams D, Malicdan MC, Bellen HJ (2024). Loss of the endoplasmic reticulum protein Tmem208 affects cell polarity, development and viability. PNAS 121: e2322582121.
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Dutta D, Kanca O, Byeon SK, Marcogliese PC, Zuo Z, Shridharan RV, Park JH, Undiagnosed Diseases Network, Lin G, Ge M, Heimer G, Kohler JN, Wheeler MT, Kaipparettu BA, Pandey A, Bellen HJ (2023). A defect in mitochondrial fatty acid synthesis impairs iron metabolism and causes elevated ceramide levels. Nature Metabolism 5: 1595-1614.
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Marcogliese PC*, Dutta D*, Sinha-Ray S, Dang NDP, Zuo Z, Wang Y, Lu D, Fazal F, Ravenscroft TA, Chung H, Kanca O, Wan JJ, Douine ED, Undiagnosed Diseases Network, Pena LDM, Yamamoto S, Nelson SF, Might M, Meyer KC, Yeo NC, Bellen HJ (2022). Loss of IRF2BPL impairs neuronal maintenance through excess Wnt signaling. Science Advances 8: eabl5613. (*Co-first author)
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Dutta D*, Briere LC*, Kanca O, Marcogliese PC, Walker MA, High FA, Vanderver A, Krier J, Carmichael N, Callahan C, Taft RJ, Simons C, Helman G, Undiagnosed Diseases Network, Wangler MF, Yamamoto S, Sweetser DA, Bellen HJ (2020). De novo mutations in TOMM70, a receptor of the mitochondrial import translocase, cause neurological impairment. Human Molecular Genetics 29: 1568-1579. (*Co-first author)​​